Výsledky

• S finanční podporou projektu vznikly v období řešení projektu, tj. 2010 až 2012následující vědecké práce (celkem 18 prací), které mají v poděkování („acknowledgements“) uvedeno registrační číslo projektu:
  
  ROK 2010:
  1. Novotna A., Doricakova A., Vrzal R., Maurel P., Pavek P., Dvorak Z. (2010) InvestigationofOrlistateffects on PXR activation and CYP3A4 expression in primaryhumanhepatocytes and humanintestinal LS174T cells. EuropeanJournalofPharmaceuticalSciences41(2):276-280. [IF 3,291]
  2. Bachleda P., Vrzal R., Dvorak Z. (2010) Resveratrolenhances NK cell cytotoxicity: Possible role for aryl hydrocarbon receptor. JournalofCellularPhysiology225(2):289-290 [IF 3,986]
  3. Dvorak Z., Pavek P. (2010)Regulationofdrug-metabolizing cytochrome P450 enzymes by glucocorticoids. DrugMetabolismReviews42(4):621-635. [IF 6,263]
  4. Dvorak Z.(2010) Berberine: a multipotentremedywithunknowncellulartarget? Poultry Science89(9):1787. [IF 1,582]
  
  
  ROK 2011:
  1. Stejskalova L., Dvorak Z.,Pavek P. (2011) Endogenous and exogenousligandsof aryl hydrocarbon receptor: Currentstateof art.CurrentDrugMetabolism12(2):198-212[IF 5,113]
  2. Monostory K., Dvorak Z. (2011) Steroid regulationofdrug-metabolizingcytochromes P450.CurrentDrugMetabolism12(2):154-172[IF 5,113]
  3. Brtko J., Dvorak Z. (2011) Role ofretinoids, rexinoids and thyroid hormone in theexpressionof cytochrome P450 enzymes. CurrentDrugMetabolism12(2):71-88[IF 5,113]
  4. Dvorak Z. (2011) Drug-druginteractions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activityinhibition. ToxicologyLetters202(2):129-132.[IF 3,230]
  5. Vrzal R., Doricakova A, Novotna A, Bachleda P., Bitman M., Pavek P., Dvorak Z (2011)Valproic acid augments vitamin D receptor-mediatedinductionof CYP24 by vitamin D3: A possible cause ofvalproic acid-inducedosteomalacia? ToxicologyLetters200(3):146-153[IF 3,230]
  6. Novotna A., Doricakova A., Vrzal R., Pavek P., Dvorak Z. (2011) Construction and characterizationofhepatocytenuclearfactor HNF4alpha1 over-expressing cell line derivedfromhumanhepatoma HepG2 cells. EuropeanJournalofPharmacology669:45-50. [IF 2,516]
  7. Stejskalova L., Vecerova L., PerezL.M., Vrzal R.,Dvorak Z., Nachtigal P., Pavek P. (2011) Aryl hydrocarbon receptor (AHR) and Aryl hydrocarbonnucleartranslocator (ARNT) expression in thehuman and ratplacentas and transcriptionactivity in humantrophoblastcultures. Toxicological Science123(1):26-36.[IF 4,652]
  8. Novotna A., Pavek P., Dvorak Z. (2011). Novel stablytransfected gene reporterhumanhepatoma cell line forassessmentof aryl hydrocarbon receptor transcriptionalactivity: Construction and characterization. Environmental&Science Technology45:10133-10139. [IF 5,228]
  9. Dvorak Z., Starha P., Travnicek Z. (2011) Evaluationof in vitro cytotoxicity of 6-benzylaminopurinecarboplatinderivativesagainsthumancancer cell lines and primaryhumanhepatocytes. Toxicology In Vitro 25(3):652-656.[IF 2,775]
  
  
  ROK 2012:
  1. Kamenickova A., Dvorak Z. (2012) Effectsofflavouredmineralwaters on AhR-CYP1A1 signalingpathway in primaryhumanhepatocytes and in humanhepatic and intestinalcancercells. Food and ChemicalToxicology50(6):1933-1939.[IF2011 2,999]
  2. Kamenickova A., Vrzal R.,Dvorak Z. (2012) Effectsofready to drink teas on AhR- and PXR-mediatedexpressionofcytochromes P450 CYP1A1 and CYP3A4 in humancancer cell lines and primaryhumanhepatocytes. Food Chemistry131:1201-1206.[IF2011 3,655]
  3. Stejskalova L., Vrzal R., Rulcova A., Dvorak Z., Pavek P.:Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast.Journal of Applied Biomedicine (in press)[IF2011 1,933]
  4. Novotna A., Pavek P., Dvorak Z.:Construction and characterizationof a reporter gene cell line forassessmentofhumanglucocorticoid receptor activation. EuropeanJournalofPharmaceuticalSciences (in press).[IF2011 3,212]
  5. Novotna A., Doricakova A.,Pavek P., Dvorak Z.:Construction and characterizationofperoxisomeproliferator-activated receptor-gamma co-activator 1 alpha (PGC-1? over-expressing cell line derivedfromhumanhepatocytecarcinoma HepG2 cells. BiomedicalPapers (in press)[IF2011 0,702]
• Data získaná v rámci řešení projektu byla prezentována na mezinárodních vědeckých konferencích (celkem 4 konference):
  1. Kameníčková A., Vrzal R., Dvořák Z.: Examination of extracts from iced-teas and flavored mineral waters on CYP1A1 expression in human hepatocytes and cell lines. 16th Interdisciplinary Toxicological Conference - TOXCON2011, Praha, 17.5.-20.5.2011. Interdisciplinary Toxicology 4(2):p. A37-A38, 2011.
  2. Dvořák Z., Kameníčková A., Vrzal R.: Examination of extracts from iced-teas on regulatory pathways of drug-metabolizing enzymes in human hepatocytes and cell lines. Abstracts of the 47th Congress of the European Societies of Toxicology (EUROTOX), Paris, Francie, 28.-31.8.2011. Toxicology Letters 205(S1):p. S140
  3. Kamenickova A., Dvorak Z.: Examinationofextractsfromflavoredmineralwaters on AhR-CYP1A1 signalingpathway in humanhepatocytes and humanhepatic and intestinalcancercells. 19th International Symposium on Microsomes and DrugOxidations; 12thEuropeanRegional ISSX Meeting; NoordwijkaanZee, TheNetherlands; 17-21 June 2012; p133-134.
  4. Kamenickova A., Vrzal R., Dvorak Z.: The influence of non-alcoholicbeverages on CYP1A1 and CYP3A4 induction in humancancer cell lines and humanhepatocytes. 17th InterdisciplinaryToxicologicalConference – TOXCON2012, Stará Lesná, Slovensko, 27.8.-31.8.2012. InterdisciplinaryToxicology5(Suppl.1):p. 42, 2012.